How to Perform a Mental State Examination (MSE)
How to Perform a Mental State Examination (MSE) The Mental State Examination (MSE) is the psychiatric equivalent of a physical examination. It provides a structured “snapshot” of a patient...

Symptoms of schizophrenia are generally divided into “positive” (additions to reality) and “negative” (withdrawals from life). In the early or prodromal phase, these signs may be subtle.
The most well-known sign. This involves perceiving things that aren’t there. While auditory hallucinations (hearing voices) are most common, it can also involve seeing, smelling, or feeling physical sensations that others do not experience.
These are fixed, false beliefs held despite evidence to the contrary. Common examples include:
Paranoia: Feeling you are being followed or spied on.
Grandiosity: Believing you have special powers or are a famous figure.
Reference: Thinking secret messages are being sent to you via the TV or radio.
It may become difficult to keep track of a conversation. A person’s speech might become jumbled, or they may jump between unrelated topics so quickly that listeners cannot follow their logic.
A person may stop responding to texts, avoid family gatherings, and prefer to spend long hours alone. This is often an early warning sign (prodrome) where the world begins to feel overwhelming or “different.”
This is not “laziness.” It is a clinical symptom where the brain’s reward system struggles to initiate even basic tasks, such as laundry, cooking, or work assignments.
A person may seem “robotic.” Their voice might become monotone, their facial expressions may not change, and they might stop making eye contact, regardless of the topic’s emotional weight.
New research highlights “brain fog” or a decline in executive function. This includes trouble with:
Working memory (remembering a short list of instructions).
Sustained attention.
Problem-solving that used to be easy.
Neglecting self-care—such as not showering for days or wearing the same clothes for a week—is a common “negative symptom” that reflects a disconnection from daily routines.
This can range from “childlike silliness” to unpredictable agitation. In some cases, it manifests as catatonia, where a person remains in a rigid or unusual posture for a long time.
Extreme changes in sleep patterns—staying up all night and sleeping all day, or experiencing chronic insomnia—often precede a full psychotic episode.
The 2026 medical consensus is clear: Earlier is better. If you or a loved one are experiencing these symptoms, you do not need to wait for a “break from reality” to seek help.
Seek an evaluation if:
Functioning Declines: You are struggling to hold a job or pass classes due to “misty” thoughts or lack of focus.
Reality Feels “Thin”: You have moments where you aren’t sure if a sound or a shadow was real.
Increased Suspicion: You find yourself unusually wary of friends or family without a clear reason.
Symptoms Last 1+ Month: If subtle changes (social withdrawal, mood shifts) persist for several weeks.
Emergency Signs
If the person is experiencing First-Episode Psychosis (FEP), seek immediate help at an Urgent Care or A&E department if there is:
A risk of self-harm or suicide.
Threats of violence toward others.
Inability to provide for basic needs (food/water) due to confusion.
| Symptom Type | What it Looks Like | Impact |
| Positive | Hallucinations, Delusions, Paranoia | Adds “new” experiences to reality. |
| Negative | Social withdrawal, Lack of speech, Apathy | Takes away from normal functioning. |
| Cognitive | Memory issues, Poor focus, “Brain fog” | Affects work and school performance. |
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