Paxlovid is a combination of two antiviral medications (nirmatrelvir and ritonavir) that prevents the COVID-19 virus from replicating. By taking these tablets within the first five days of symptoms, high-risk patients can significantly reduce their chance of hospitalisation.
As of April 2026, NICE has widened access to Paxlovid to include approximately 5.3 million people. Beyond the severely immunocompromised, eligibility now includes all adults aged 85+, care home residents aged 70+, and patients with end-stage heart failure or those on organ transplant waiting lists.
The NHS no longer automatically contacts you after you report a positive result. Responsibility has shifted to the patient. Most local Integrated Care Boards (ICBs) now provide an online self-referral portal. If you are high-risk, you must proactively visit your local NHS website or contact your GP surgery to trigger an assessment.
Paxlovid must be started within five days of your first symptoms. Because 2026 variants like “Cicada” often peak later, do not wait for a strong positive line. If you feel unwell, use the 48-hour serial testing rule and seek a referral the moment a positive result appears to stay within this critical window.
Once referred, a Clinical Support Unit (CSU) clinician will review your medications for potential interactions (common with statins and blood thinners). The most frequent side effect in 2026 remains “Paxlovid Mouth”—a temporary metallic taste. Your kidney function (eGFR) will also be checked to ensure the dosage is safe.
Eligible patients are still entitled to free lateral flow tests from local pharmacies. If the CSU approves your treatment, they will typically arrange for the medication to be delivered to your home or made available for a representative to collect, ensuring you can begin the 5-day course immediately.
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