10 drugs that are safer in pregnancy

  • No drug is completely safe in pregnancy
  • But you always have to weigh the up the risks to the mother and baby of not treating the illness.
  • Here’s a list of 10 drugs that are considered relatively safer in pregnancy, along with some key considerations.
  1. Paracetamol (Acetaminophen): For pain and fever relief.
  1. Penicillin: For bacterial infections (e.g. UTIs; where Nitrofurantoin is also used).
  1. Metoclopramide: For nausea and vomiting (short-term use).
  1. Folic Acid: Essential for preventing neural tube defects.
  1. Insulin: For managing diabetes.
  1. Iron Supplements: For treating iron deficiency anaemia.
  1. Low-dose Aspirin: For preventing pre-eclampsia in high-risk pregnancies (under specialist guidance).
  1. Metformin: For gestational diabetes or polycystic ovary syndrome (PCOS), though insulin may be preferred in some cases.
  1. Ondansetron: For severe nausea and vomiting (used cautiously).
  1. Ranitidine (when available) or Omeprazole: For heartburn and acid reflux.

Prescribing in pregnancy

When prescribing medications in pregnancy, consider the following:
  • Always consult the UK Teratology Information Service (UKTIS) or the British National Formulary (BNF) for the most current guidance.
  • Weigh the benefits and risks of each medication.
  • Collaborate with obstetric specialists when managing complex cases.
  • Monitor patients closely for any adverse effects.

Other resource

Drugs that are less safe in pregnancy